This Core is led by Dr. Van Dyke who is nationally known for her work on genetically engineered mouse tumor models, particularly relating to the role of the Rb and p53 tumor suppressor pathways. Dr. Van Dyke shared the initial leadership of the NCI Mouse Models of Human Cancer Consortium and continues as an active PI on one of the MMHC grants featuring brain tumors.
This Core will support the animal model needs of Projects 1-5. A series of well-defined mouse tumor models are currently available at the LCCC, including genetically defined mouse models for breast, colon, pancreatic, melanoma, lung carcinoma, and brain tumors. Additional models for prostate and metastatic disease are available as CCNE projects mature. The Animal Models Core will maintain colonies of these animals and produce them for the investigators as needed. In cases where new transgenic and/or gene-targeted mouse lines may be required, the core will:
* assist investigators in designing transgenic and gene targeting vectors
* provide genomic clones and plasmid backbones to the investigator for constructing the vectors
* create new transgenic and gene-targeted mouse lines for the investigators
* breed and genotype the animals for experiments
* assist in experimental procedures
Associated technologies, such as cryopreservation and ovary transplants, are also available to support C-CCNE research.
Animal Models
